$53 Flights from San Diego (SANA) to St Louis (STL)

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Flight deals from San Diego to St Louis

Looking for a cheap last-minute deal or the best round-trip flight from San Diego to St Louis? Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from San Diego to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like San Diego to St Louis flights are currently cheapest in January.

Direct flights from San Diego to St Louis

San Diego to St Louis: Alternative routes

Compare routes from San Diego to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

San Diego to St Louis: Flight information

The things to know before you go.
Cheapest flight found$53
Cheapest month to flyJanuary
Average flight time3 hrs, 35 mins
Most popular airlineSouthwest Airlines
Average flights per week36

Finding cheap flights from San Diego to St Louis: Frequently asked questions

The best price we found for a round-trip flight from San Diego to St Louis is $140. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
3 hours and 35 minutes is the average flight time from San Diego to St Louis.
Southwest Airlines flies direct from San Diego to St Louis.
There are 11 flights per week flying from San Diego to St Louis, as of December 2025.
The cheapest month to fly from San Diego to St Louis is usually January.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from San Diego to St Louis Airport on Friday, January 16, 2026.
Yes – the average flight time is 3 hours and 35 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.

Traveling from San Diego to Lambert-St. Louis International Airport (STL): What you need to know

  • Kick off your journey at one of San Diego's main airports, San Diego International Airport (SAN) or McClellan-Palomar Airport (CLD). Check out your options for booking a flight from San Diego to Lambert-St. Louis International Airport (STL) leaving from either of these.

  • The average duration of a direct San Diego to Lambert-St. Louis International Airport flight is 3 hours 40 minutes.

  • St Louis is two hours ahead of San Diego. Lambert-St. Louis International Airport is located in St Louis, which follows the UTC-5 timezone.

  • The busiest route is from San Diego International Airport (SAN) to Lambert-St. Louis International Airport (STL). There are 5 direct services each week. Southwest Airlines operates a 6:20am departure between SAN and STL.

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are golden rules for stress-free travel. Make sure you're at the airport on time to board your flight from San Diego to STL.

  • During peak travel periods, expect extended wait times and show up earlier. Aim for at least two hours ahead for domestic flights and as much as four hours for international journeys.

Airports in San Diego

San Diego International Airport (SAN)

  • San Diego International Airport (SAN) provides a hassle-free way to reach your destination. Nonstop flights from San Diego to Lambert-St. Louis International Airport (STL) operate out of this terminal.

  • When departing from SAN, you can take a direct flight from San Diego to Lambert-St. Louis International Airport with Southwest Airlines.

  • Southwest Airlines is the airline with the highest passenger demand for flights from SAN to STL.

  • Southwest Airlines is the most punctual carrier on this route.

  • The journey from central San Diego to SAN takes around 20 minutes by public transport. If you ride-share, drive or get a cab, you'll cover the 3 miles in 10 minutes or so, depending on traffic conditions.

  • Planning to catch an early flight from San Diego to Lambert-St. Louis International Airport? Avoid rushing to the terminal (and catch some extra z's) by picking one of these hotels near San Diego International Airport:

  • 71.38% of flights leaving from San Diego International Airport touch down at their destination on time.

  • SAN is located at N Harbor Dr.

McClellan-Palomar Airport (CLD)

  • On public transport, you can travel from central San Diego to CLD in around 2 hours 15 minutes. The terminal is roughly 35 miles away, and making the journey by car will take approximately 40 minutes.

  • Get a head start on your vacation with an additional night away from home. Before catching your San Diego to STL flight, kick back in one of these hotels near McClellan-Palomar Airport:

About Lambert-St. Louis International Airport (STL)

Getting from Lambert-St. Louis International Airport (STL) to central St Louis

  • Central St Louis is roughly 10 miles from Lambert-St. Louis International Airport. Travel times by cab or car rental will vary depending on traffic conditions and time of day, so do a little research ahead of your trip.

  • Traveling on public transport takes around 35 minutes.

How to find the cheapest flights from San Diego to Lambert-St. Louis International Airport (STL)

  • Right now, $53 is the best price we've found for a one-way ticket from San Diego to Lambert-St. Louis International Airport. The cheapest price for a return flight is $140. Keep in mind fares can change due to availability at the time of booking.

  • Booking ahead of time is often the key to finding a cheap flight from San Diego to STL. Fares tend to rise as seats fill up, so the closer your departure date, the more expensive your ticket may be.

  • If you're flexible with your travel dates, use the 'Whole month' search tool. It'll give you the cheapest price in each month when searching for your San Diego to Lambert-St. Louis International Airport ticket.

  • There's no need to search every day to find out if fares have dropped when you create a Price Alert. We'll notify you as soon as a better deal comes up on plane tickets from San Diego to STL.

  • Find an affordable flight from San Diego to Lambert-St. Louis International Airport by using filters. Choose your ideal duration, departure time and airlines, then sort the results by 'Cheapest' for the best deals.

The best time to fly from San Diego to Lambert-St. Louis International Airport (STL)

  • It's time to figure out when to book your flight from San Diego to Lambert-St. Louis International Airport (STL). July is the most popular month to visit St Louis. If a slower pace sounds more appealing, go in April.

  • The warmest month in St Louis is July, with temperatures ranging between 63ºF and 91ºF. Book your San Diego to STL plane ticket then if you enjoy this type of weather.

  • If you'd rather travel in cooler conditions, search for a cheap ticket from San Diego to Lambert-St. Louis International Airport in January when temperatures are between 18ºF and 45ºF.

More about St Louis

Explore more of the United States

  • You've seen St Louis, now it's time to explore other parts of the United States. Travel about 160 miles east to Evansville to tick off its must-visit sights. From Mesker Park Zoo to Riverfront Park and Evansville Zoological Society, you'll have a full itinerary ahead.

  • Around 110 miles west of St Louis, Columbia is another essential stop in the United States. Experience this destination's highlights firsthand at Sentinel Park, Museum of Art and Archaeology and Bur Oak Brewing Company.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.